Interferon-gamma-release assays: Better than tuberculin skin testing?
نویسندگان
چکیده
Although the tuberculin skin test has long been the standard for detecting latent tuberculosis infection, it has many limitations. Interferon-gamma-release assays are gaining acceptance as an alternative. In this paper we present cases to illustrate how these new tests can be used and how to interpret the results.
منابع مشابه
Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence
A profusion of articles have been published on the accuracy and uses of interferon-gamma releasing assays. Here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for different indications for the use of these tests. We conclude that both tests ar...
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For nearly a century, the tuberculin skin test was the only tool available for the detection of latent tuberculosis infection. A recent breakthrough has been the development of T-cell-based interferon-gamma release assays. Current evidence suggests interferon-gamma release assays have higher specificity than the tuberculin skin test, better correlation with surrogate markers of exposure to Myco...
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Latent tuberculosis infection (LTBI) is a subclinical infection with Mycobacteria tuberculosis complex without any clinical, bacteriological or radiological evidence of manifest TB disease.1 LTBI results from contact with an infectious case of TB. It is characterised by the presence of mycobacterial T-cell responses, assessed by either the tuberculin skin test (TST) or more recently, interferon...
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ورودعنوان ژورنال:
- Cleveland Clinic journal of medicine
دوره 77 9 شماره
صفحات -
تاریخ انتشار 2010